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Literature summary for 3.13.2.1 extracted from

  • Liau, M.C.; Chang, C.F.; Saunders, G.F.; Tsai, Y.H.
    S-Adenosylhomocysteine hydrolases as the primary target enzymes in androgen regulation of methylation complexes (1981), Arch. Biochem. Biophys., 208, 261-272.
    View publication on PubMed
Search for more literature for 3.13.2.1

Activating Compound

Activating Compound Comment Organism Structure
5alpha-dihydrotestosterone stimulating and stabilizing, promotes formation of ternary complexes, restores specific activity after hypophysectomy Rattus norvegicus

General Stability

General Stability Organism
isozymes become unstable after DEAE-cellulose chromatography, ternary tRNA complexes are most stable form of enzymes, testosterone promotes formation of ternary complexes and prevents inactivation, hyperphysectomy leads to dissociation of ternary complexes and to loss of specific activity, stability of enzyme also improved by 5alpha-dihydrotestosterone Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00033
-
 adenosine column-retained isozyme Rattus norvegicus
0.00181
-
 adenosine flow-through isozyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Rattus norvegicus
-
 adenosine + L-homocysteine
-
 ?
S-adenosyl-L-homocysteine + H2O Rattus norvegicus Sprague-Dawley
-
 adenosine + L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
Novikoff hepatoma cell
-
 Rattus norvegicus
-
prostate gland
-
 Rattus norvegicus
-
testis
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus adenosine + L-homocysteine
-
 ?
S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus Sprague-Dawley adenosine + L-homocysteine
-
 ?